COVID-19 update for Acthar® Gel (repository corticotropin injection)

Acthar Patient Support is by your side during these unpredictable times. Your care is of the utmost importance to us, and we will continue to remain open and provide one-on-one support.

Your dedicated team is ready to help.
Please call Acthar Patient Support at 1-888-435-2284
Monday through Friday, 8 am to 9 pm ET
Saturday, 9 am to 2 pm ET


© 2020 Mallinckrodt. US-2000668 03/20

Educational Tools and Useful Links

The below resources and information can help support you while you take Acthar.

Thumbnail of Patient Brochure

Your Guide to Acthar

This guide offers information about Acthar, how it is thought to work, and no-cost support resources that may help you.

Thumbnail of Patient Brochure

Step-by-Step Injection Instructions

This guide helps you with taking your treatment. It walks you through every step of the injection process.

Thumbnail of Patient Support Brochure

Acthar Treatment Journal

Use this tool to keep track of your Acthar treatment and write down questions for your healthcare provider.

Thumbnail of Treating Proteinuria With Acthar

Treating Proteinuria With Acthar

This brochure describes the causes and symptoms of nephrotic syndrome, how Acthar may help, and resources available from Acthar Patient Support.

Thumbnail of Managing Nephrotic Syndrome Due to Post-Transplant FSGS

Managing Nephrotic Syndrome Due to Post-Transplant FSGS

This brochure explains why reducing high protein levels in urine is important, how Acthar may fit into your treatment plan, and how to receive free training and assistance options from Acthar Patient Support.

Thumbnail of Understanding Proteinuria in Nephrotic Syndrome

Understanding Proteinuria in Nephrotic Syndrome

This brochure helps you understand what proteinuria in nephrotic syndrome is, how proteinuria occurs, and what the causes may be. It also includes talking points to discuss with your doctor about your treatment plan.

See How Acthar Is Injected

These educational videos will show you how to inject Acthar.

Injecting Beneath the Skin

Subcutaneous (SC) injection video

Injecting under the skin1:22

Injecting Into a Muscle

Intramuscular (IM) injection video

Injecting into a muscle1:19

Meet Don: Living With Proteinuria in Nephrotic Syndrome

In this video, Don talks about how his life changed when he was diagnosed with proteinuria in nephrotic syndrome, and how Acthar helped him achieve remission of proteinuria.

Meet Don: Living With Proteinuria in Nephrotic Syndrome11:35

Although managing your excess urinary protein can be difficult, there are many resources you can look to for additional information and support.

These organizations can provide you with more information about your proteinuria in nephrotic syndrome:

NephCure Kidney International
A nonprofit organization focused exclusively on supporting patients and finding better treatments and cures for nephrotic syndrome and other rare, protein-spilling kidney diseases.

National Kidney Foundation
The National Kidney Foundation (NKF) is the largest, most comprehensive, and longstanding patient-centric organization dedicated to the awareness, prevention, and treatment of kidney disease in the U.S.

American Association of Kidney Patients (AAKP)
The AAKP is the oldest and largest fully independent kidney patient organization in the U.S. AAKP is dedicated to improving the quality of life and long-term outcomes for kidney patients through education, advocacy, patient engagement and the fostering of patient communities.

American Kidney Fund
A nonprofit fighting kidney disease on all fronts with programs of prevention, early detection, financial support, disease management, clinical research, innovation and advocacy.

This site may identify third-party organizations and provide links to third-party websites or other third-party information ("Third-Party Content"). The Third-Party Content is meant for informational purposes only, is not endorsed by or under the control of Mallinckrodt, and is not meant to replace a physician's medical advice. Mallinckrodt has no responsibility or liability for and makes no representations whatsoever about any Third-Party Content.

Acthar is a prescription medicine for the reduction of proteinuria in people with nephrotic syndrome of the idiopathic type (unknown origin) without uremia (accumulation of urea in the blood due to malfunctioning kidneys) or that due to lupus erythematosus (lupus).

Expand

IMPORTANT SAFETY
INFORMATION

DO NOT take Acthar until you have talked to your doctor if you have any of the following conditions:

  • A skin condition called scleroderma
  • Bone density loss or osteoporosis
  • Any infections, including fungal, bacterial, or viral
Expand

What is Acthar® Gel?

Acthar is a prescription medicine for the reduction of proteinuria in people with nephrotic syndrome of the idiopathic type (unknown origin) without uremia (accumulation of urea in the blood due to malfunctioning kidneys) or that due to lupus erythematosus (lupus).

IMPORTANT SAFETY INFORMATION

DO NOT take Acthar until you have talked to your doctor if you have any of the following conditions:

  • A skin condition called scleroderma
  • Bone density loss or osteoporosis
  • Any infections, including fungal, bacterial, or viral
  • Eye infections, such as ocular herpes simplex
  • Had recent surgery
  • Stomach ulcers or a history of stomach ulcers
  • Heart failure
  • Uncontrolled high blood pressure
  • Allergies to pig-derived proteins
  • Have been given or are about to receive a live or live attenuated vaccine
  • Suspected congenital infections (in children under 2 years of age)
  • Cushing's syndrome or Addison's disease

What is Acthar® Gel?

Acthar is a prescription medicine for the reduction of proteinuria in people with nephrotic syndrome of the idiopathic type (unknown origin) without uremia (accumulation of urea in the blood due to malfunctioning kidneys) or that due to lupus erythematosus (lupus).

Acthar is injected beneath the skin or into the muscle.

Tell your doctor about any other health problems that you have. Give your doctor a complete list of medicines you are taking. Include all nonprescription medicines, vitamins, and herbal supplements that you are taking.

What is the most important information I should know about Acthar?

  • Never inject Acthar directly into a vein
  • Always inject Acthar beneath the skin or into the muscle
  • Follow your doctor's instructions for injecting Acthar
  • Never stop treatment suddenly unless your doctor tells you to do so
  • Try not to miss any scheduled doctor's appointments. It is important for the doctor to monitor you while taking Acthar

Acthar and corticosteroids have similar side effects.

  • You may be more likely to get new infections. Also, old infections may become active. Tell your doctor if you see any signs of an infection. Contact your doctor at the first sign of an infection or fever. Signs of infection are fever, cough, vomiting, or diarrhea. Other signs may be flu or any open cuts or sores
  • When taking Acthar long term, your adrenal gland may produce too much of a hormone called cortisol. This can result in symptoms of Cushing's syndrome. This may cause increased upper body fat, a rounded "moon" face, bruising easily, or muscle weakness
  • Sometimes when you stop taking Acthar long term, your body may not produce enough natural cortisol. This is called "adrenal insufficiency." Your doctor may prescribe a steroid medicine to protect you until the adrenal gland recovers
  • You might develop high blood pressure, or retain too much fluid. As a result of this, your doctor may recommend some changes to your diet, such as eating less salt and taking certain supplements
  • Vaccines may not work well when you are on Acthar. Talk to your doctor about which vaccines are safe to use when you are taking Acthar
  • Acthar may hide symptoms of other diseases. This can make it more difficult for your doctor to make a diagnosis if something else is going on
  • Stomach or intestinal problems. Acthar may increase the risk of bleeding stomach ulcers. Tell your doctor if you have stomach pains, bloody vomit, bloody or black stools, excessive tiredness, increased thirst, difficulty breathing, or increased heart rate
  • Taking Acthar can make you feel irritable or depressed. You may also have mood swings or trouble sleeping
  • If you have other conditions, such as diabetes or muscle weakness, you may find they get worse
  • You might develop certain eye conditions, such as cataracts, glaucoma, or optic nerve damage
  • Your body may develop allergies to Acthar. Signs of allergic reaction are:
    • Skin rash and itching
    • Swelling of the face, tongue, lips, or throat
    • Trouble breathing
  • Long-term Acthar use can affect growth and physical development in children. This can be reversed when Acthar is no longer needed
  • Acthar may cause osteoporosis (weak bones)
  • Acthar might harm an unborn baby. Therefore, tell your doctor if you are pregnant or plan on becoming pregnant

What are the most common side effects of Acthar?

The most common side effects of Acthar are similar to those of steroids. They include:

  • Fluid retention
  • High blood sugar
  • High blood pressure
  • Behavior and mood changes
  • Changes in appetite and weight

Specific side effects in children under 2 years of age include:

  • Increased risk of infections
  • High blood pressure
  • Irritability
  • Symptoms of Cushing's syndrome
  • Thickening of the heart muscle (cardiac hypertrophy)
  • Weight gain

The above side effects may also be seen in adults and children over 2 years of age.

These are not all of the possible side effects of Acthar.

Tell your doctor about any side effect that bothers you, or that does not go away. Call your doctor or pharmacist for medical advice about side effects. You may report side effects to the FDA. Call 1-800-FDA-10881-800-FDA-1088 or visit www.fda.gov/medwatch. You may also report side effects by calling 1-800-844-28301-800-844-2830.

Please see full Prescribing Information for additional Important Safety Information.